Suguler Kadriye Cansu, Topak Osman Zulkif, Ozdel Osman, Acikbas Ibrahim, Urganci Aysen Buket Er
Department of Psychiatry, University of Pamukkale, Denizli, Turkey.
Department of Medical Biology, University of Pamukkale, Denizli, Turkey.
Clin Psychopharmacol Neurosci. 2025 Aug 31;23(3):356-367. doi: 10.9758/cpn.24.1244. Epub 2025 Jan 9.
The study was designed to compare the expression levels of IL-6 mRNA, long non-coding RNA (lncRNA) NRON (non-coding repressor of the nuclear factor of activated T cells [NFAT]) and TMEVPG1 (Theiler's murine encephalomyelitis virus persistence candidate gene 1) which play critical roles in the regulation of immune function, and to investigate relationship between expression levels and symptom type and the cognitive functions in patients with schizophrenia and schizoaffective disorder.
The study included 84 participants (27 patients with schizophrenia, 27 with schizoaffective disorder, and 30 healthy subjects). The lncRNA (TMEVPG1 and NRON) and IL-6 mRNA expression analysis was measured with the real-time PCR method. The Wisconsin Card Sorting Test, the Stroop Test, Clinical Global Impression Scale, Positive and Negative Symptoms Scale, Young Mania Rating Scale and the Hamilton Depression Rating Scale were applied.
The lncRNA TMEVPG1 expression level was determined to be higher in the patient groups than controls. The TMEVPG1 was able to differentiate schizophrenia cases from the controls. In the schizoaffective group, a positive correlation was determined between NRON expression and positive symptomatology, and an increase in NRON expression was determined to make a moderate contribution to cognitive dysfunction. NRON expression was decreased as the dose of antipsychotic drug increased in the schizophrenia group.
The results of this study demonstrated that there are significant differences between schizophrenia and schizoaffective disorder in terms of inflammatory markers and their relationship between the symptom type or cognitive functions.
本研究旨在比较在免疫功能调节中起关键作用的白细胞介素-6（IL-6）信使核糖核酸（mRNA）、长链非编码核糖核酸（lncRNA）NRON（活化T细胞核因子[NFAT]的非编码抑制因子）和TMEVPG1（泰勒氏鼠脑脊髓炎病毒持续感染候选基因1）的表达水平，并探讨精神分裂症和分裂情感性障碍患者的表达水平与症状类型及认知功能之间的关系。
本研究纳入84名参与者（27名精神分裂症患者、27名分裂情感性障碍患者和30名健康受试者）。采用实时聚合酶链反应（PCR）法测量lncRNA（TMEVPG1和NRON）和IL-6 mRNA的表达分析。应用威斯康星卡片分类测验、斯特鲁普测验、临床总体印象量表、阳性和阴性症状量表、青年躁狂评定量表和汉密尔顿抑郁评定量表。
确定患者组中lncRNA TMEVPG1的表达水平高于对照组。TMEVPG1能够区分精神分裂症病例与对照组。在分裂情感性障碍组中，确定NRON表达与阳性症状之间存在正相关，并且确定NRON表达的增加对认知功能障碍有中度影响。在精神分裂症组中，随着抗精神病药物剂量的增加，NRON表达降低。
本研究结果表明，精神分裂症和分裂情感性障碍在炎症标志物及其与症状类型或认知功能之间的关系方面存在显著差异。
