Wang Huanbing, Chen Xuesi, Pan Caiyuan
Department of Polymer Science and Engineering, Joint Laboratory of Polymer Thin Films and Solution, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
J Colloid Interface Sci. 2008 Apr 1;320(1):62-9. doi: 10.1016/j.jcis.2007.11.051. Epub 2008 Feb 19.
Linear poly(ethylenimine)-graft-poly(ethylene glycol)s (LPEI-g-PEG) with various degrees of grafting and molecular weights were synthesized by Michael addition reaction of LPEI with methoxy poly(ethylene glycol) acrylate. The graft copolymers display pH-sensitive behaviors, and pH variation of the copolymer solution induced the aggregation of graft copolymers, forming the micelles with different sizes. The dynamic light scattering method was used to study the effects of ionic strength, chain composition and pH on hydrodynamic radius. With solvent evaporation of the micelles solution, various morphologies were formed.
通过线性聚乙烯亚胺（LPEI）与甲氧基聚乙二醇丙烯酸酯的迈克尔加成反应，合成了具有不同接枝度和分子量的线性聚乙烯亚胺接枝聚乙二醇（LPEI-g-PEG）。接枝共聚物表现出pH敏感行为，共聚物溶液的pH变化会诱导接枝共聚物聚集，形成不同尺寸的胶束。采用动态光散射法研究了离子强度、链组成和pH对流体力学半径的影响。随着胶束溶液的溶剂蒸发，形成了各种形态。
