Carragher Damian M, Rangel-Moreno Javier, Randall Troy D
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, United States.
Semin Immunol. 2008 Feb;20(1):26-42. doi: 10.1016/j.smim.2007.12.004. Epub 2008 Feb 19.
Ectopic or tertiary lymphoid tissues develop at sites of inflammation or infection in peripheral, non-lymphoid organs. These tissues are architecturally similar to conventional secondary lymphoid organs, with separated B and T cell areas, specialized populations of dendritic cells, well-differentiated stromal cells and high endothelial venules. Ectopic lymphoid tissues are often associated with the local pathology that results from chronic infection or chronic inflammation. However, there are also examples in which ectopic lymphoid tissues appear to contribute to local protective immune responses. Here we review how ectopic lymphoid structures develop and function in the context of local immunity and pathology.
异位或三级淋巴组织在外周非淋巴器官的炎症或感染部位形成。这些组织在结构上与传统的二级淋巴器官相似，有分开的B细胞和T细胞区域、特殊的树突状细胞群体、分化良好的基质细胞和高内皮微静脉。异位淋巴组织常与慢性感染或慢性炎症导致的局部病理状况相关。然而，也有一些例子表明异位淋巴组织似乎有助于局部保护性免疫反应。在此，我们综述异位淋巴结构在局部免疫和病理背景下是如何形成和发挥功能的。
