Silva-Sanchez Aaron, Randall Troy D, Meza-Perez Selene
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Methods Mol Biol. 2018;1845:1-15. doi: 10.1007/978-1-4939-8709-2_1.
Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation and resolve infection. Many of the mechanisms controlling the formation and function of tertiary lymphoid structures have been identified, in part by experimentally triggering their formation using defined stimuli under controlled conditions. Here, we introduce the experimental and pathological conditions in which tertiary lymphoid tissues are formed, describe the mechanisms linked to their formation, and discuss their functions in the context of both infection and inflammation.
三级淋巴结构（TLOs），也被称为异位淋巴结构，与慢性感染和炎症性疾病相关。尽管它们与病理状况有关，但这些结构实际上是免疫系统正常的组成部分，尽管是短暂的，并且有助于局部免疫反应，旨在减轻炎症并解决感染。控制三级淋巴结构形成和功能的许多机制已被确定，部分是通过在受控条件下使用特定刺激物实验性地触发它们的形成来实现的。在这里，我们介绍三级淋巴组织形成的实验和病理条件，描述与其形成相关的机制，并在感染和炎症的背景下讨论它们的功能。
