Neuroimaging findings in isoniazid central nervous system toxicity, presumed intramyelinic edema.

作者信息

Hawkes Michael, Kitai Ian, Blaser Susan, Cohen Eyal, Bitnun Ari, Fluss Joel, Tran Dat

机构信息

Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

出版信息

Eur J Paediatr Neurol. 2008 Nov;12(6):512-5. doi: 10.1016/j.ejpn.2007.12.002. Epub 2008 Feb 20.

DOI:10.1016/j.ejpn.2007.12.002

PMID:18243740

Abstract

We describe the clinical course and striking neuroimaging findings of a child with central nervous system toxicity due to isoniazid. Serum isoniazid level was in the toxic range, the result of a dispensing error as well as a possible pharmacogenetic factor. We postulate that these imaging findings were the result of intramyelinic edema, previously described in experimental animal models of isoniazid toxicity.

摘要