Ben Ammar C N, Kochbati L, Chraeit N, Amrouche A, Gargouri W, Frikha H, Besbes M, Abdallah M B, Maalej M
Service de radiothérapie-oncologie, institut Salah-Azaiz, boulevard du 9 avril, 1006 Bab-Saadoun, Tunis, Tunisie.
Cancer Radiother. 2008 Mar;12(2):73-7. doi: 10.1016/j.canrad.2007.12.004. Epub 2008 Feb 20.
This study aims to evaluate local failure patterns in node negative breast cancer patients treated with post-mastectomy radiotherapy including internal mammary chain only.
Retrospective analysis of 92 internal or central-breast node-negative tumours with mastectomy and external irradiation of the internal mammary chain at the dose of 50 Gy, from 1994 to 1998.
Local recurrence rate was 5 % (five cases). Recurrence sites were the operative scare and chest wall. Factors associated with increased risk of local failure were age < or = 40 years and tumour size greater than 20mm, without statistical significance.
Post-mastectomy radiotherapy should be discussed for a sub-group of node-negative patients with predictors factors of local failure such as age < or = 40 years and larger tumour size.
本研究旨在评估仅接受包括内乳链在内的乳房切除术后放疗的淋巴结阴性乳腺癌患者的局部复发模式。
回顾性分析1994年至1998年间92例接受乳房切除术及50 Gy剂量内乳链外照射的内侧或中央型乳房淋巴结阴性肿瘤患者。
局部复发率为5%（5例）。复发部位为手术瘢痕和胸壁。与局部复发风险增加相关的因素为年龄≤40岁和肿瘤大小大于20mm，但无统计学意义。
对于年龄≤40岁和肿瘤较大等具有局部复发预测因素的淋巴结阴性患者亚组，应讨论乳房切除术后放疗。
