Teboul M, Bismuth J, Gharbi-Chihi J, Valette A, Bonne J, Ghiringhelli O, Torresani J
INSERM U 38 et U 260*, Faculté de Médecine, Marseille.
Ann Endocrinol (Paris). 1991;52(6):406-9.
In the murine preadipocyte cell line Ob 17, T3 is known as being necessary at an early step of adipose differentiation for the expression of late markers, but not necessary for the expression of early markers. These cells contain nuclear T3 receptors (RT3) which are products of c-erb A alpha proto oncogenes, and are down-regulated by T3. In these cells, retinoic acid (AR) inhibits the adipose differentiation and the expression of early and late markers, and T3 sensitizes the cells to the inhibitory action of AR. We also show that AR down-regulates the expression of RT3 at both pre- and post-translational levels. This inhibition is dependent on AR concentration, a peculiar sensitivity to AR being observed at an early step of development.
在小鼠前脂肪细胞系Ob 17中，已知三碘甲状腺原氨酸（T3）在脂肪分化的早期阶段对于晚期标志物的表达是必需的，但对于早期标志物的表达并非必需。这些细胞含有核T3受体（RT3），它们是c-erb Aα原癌基因的产物，并受T3下调。在这些细胞中，视黄酸（AR）抑制脂肪分化以及早期和晚期标志物的表达，而T3使细胞对AR的抑制作用敏感。我们还表明，AR在翻译前和翻译后水平下调RT3的表达。这种抑制作用取决于AR的浓度，在发育早期观察到对AR有特殊的敏感性。
