Bahrami Gholamreza, Masoumi Masoumali, Rahimi Zoherh
Medical Biology Research Center, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Thromb Thrombolysis. 2009 Feb;27(2):185-90. doi: 10.1007/s11239-008-0198-x. Epub 2008 Feb 1.
This study was aimed to evaluate composition and possible co-existence of change in fatty acids of aorta artery and adipose tissue in two groups of patients with different degree of atherosclerosis.
Twenty-one angiographically documented coronary artery diseases (CAD) patients, and the same numbers of age, sex and body mass index-matched angiographically documented non CAD patients enrolled in this study. They were operated electively for coronary artery bypass grafting (CABG) or aortic valve replacement surgery (AVR), respectively. Small segments of ascending aorta artery and adipose tissue were dissected form the two groups during open heart surgery and subjected to fatty acid analysis.
The results showed that in the CAD group, amounts of saturated and omega6 unsaturated fatty acids were higher, while the percent of monounsaturated and omega3 unsaturated fatty acids were lower than the non CAD patients for both aorta artery and adipose tissue samples. A moderate correlation was seen between amounts of fatty acids in adipose tissue and aorta artery.
As there are many reports which show that adipose tissue can only be used as a suitable indicator of dietary intake of exogenous fatty acids (e.g. polyunsaturated and trans fatty acids), our study suggests that modification of fatty acids with endogenous synthesis and metabolism (e.g. saturated and monounsaturated fatty acids) which were observed in both adipose tissue and aorta artery of CAD patients, may be produced during atherogenesis.
本研究旨在评估两组不同动脉粥样硬化程度患者的主动脉和脂肪组织中脂肪酸的组成及可能的共存变化。
本研究纳入了21例经血管造影证实的冠心病（CAD）患者，以及相同数量的年龄、性别和体重指数匹配的经血管造影证实的非CAD患者。他们分别接受了冠状动脉旁路移植术（CABG）或主动脉瓣置换手术（AVR）。在心脏直视手术期间，从两组患者中切取小段升主动脉和脂肪组织，并进行脂肪酸分析。
结果显示，在CAD组中，主动脉和脂肪组织样本的饱和脂肪酸和ω6不饱和脂肪酸含量均高于非CAD患者，而单不饱和脂肪酸和ω3不饱和脂肪酸的百分比则低于非CAD患者。脂肪组织和主动脉中的脂肪酸含量之间存在中度相关性。
由于有许多报告表明脂肪组织只能用作外源脂肪酸（如多不饱和脂肪酸和反式脂肪酸）膳食摄入量的合适指标，我们的研究表明，在CAD患者的脂肪组织和主动脉中均观察到的内源性合成和代谢引起的脂肪酸改变（如饱和脂肪酸和单不饱和脂肪酸）可能在动脉粥样硬化形成过程中产生。
