Cui Han-bin, Wang Sheng-huang, Wang Dong-qi, Cui Chang-cong, Chen Xin-yi, Chen Xiao-min, Zhang Zheng, Zhang Hong-kao, Bai Feng, Muhlestein Joseph B
Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an.
Chin Med Sci J. 2007 Dec;22(4):216-23.
To investigate the levels of cardiovascular disease risk factors and their relations to clinical phenotype associated with coronary artery disease (CAD).
The subjects were recruited from five independent cardiovascular centers. Coronary angiography was employed to define the CAD with stenosis in each major vessel > or = 70% and control with stenosis < 10% in every lesion. The classic risk factors including family history, body mass index, smoking habits, hypertension, diabetes mellitus, and serum lipid levels were surveyed according to established criteria. Associations between risk levels and clinical phenotypes were assessed by case control and correlation analysis.
A total of 762 individuals were collected, including 481 men and 281 women, aged from 17 to 81 (mean 60 +/- 10) years. The patients with CAD accounted for 55.5% of all participants, and controls 44.5%, respectively. Compared with the pattern in published data, our study showed that mean serum high density lipoprotein cholesterol (HDL-C) level was significantly lower (P < 0.001) and triglycerides was significantly higher (P < 0.001), while total cholesterol (TC) and low density lipoprotein cholesterol levels were comparative (both P > 0.05). The prevalence of low HDL-C (< 40 g/L) and hypertriglyceridemia (> 150 g/L) were 27.2% and 41.4%, respectively. Mean serum levels of HDL-C and apolipoprotein A1 were significantly higher in female subjects than in male (P < 0.001). Lower HDL-C functioned as an independent risk factor for CAD only in men (RR = 2.8, 95% CI: 1.5-4. 2, P < 0.001), yet increased non-HDL cholesterol combined with diabetes mellitus and obesity seemed to play a key role in the development of CAD in women. Similarity in risk association with CAD was found for hypertension and TC/HDL ratio in male and female subjects, while family history had no relationship with the presence of CAD.
It is remarkable that emphasis of intervention in future should be given on the prevalent low serum HDL-C and its strong risk correlation with the presence of CAD in male subjects of Chinese Han population.
研究心血管疾病危险因素水平及其与冠状动脉疾病（CAD）临床表型的关系。
研究对象来自五个独立的心血管中心。采用冠状动脉造影术定义CAD，即各主要血管狭窄≥70%，对照组各病变狭窄<10%。根据既定标准调查家族史、体重指数、吸烟习惯、高血压、糖尿病和血脂水平等经典危险因素。通过病例对照和相关性分析评估危险因素水平与临床表型之间的关联。
共收集762例个体，其中男性481例，女性281例，年龄17至81岁（平均60±10岁）。CAD患者占所有参与者的55.5%，对照组占44.5%。与已发表数据的模式相比，本研究显示平均血清高密度脂蛋白胆固醇（HDL-C）水平显著降低（P<0.001），甘油三酯显著升高（P<0.001），而总胆固醇（TC）和低密度脂蛋白胆固醇水平相当（均P>0.05）。低HDL-C（<40g/L）和高甘油三酯血症（>150g/L）的患病率分别为27.
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