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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bhargava K P, Kulshrestha V K, Srivastava Y P

Br J Pharmacol. 1977 May;60(1):77-81. doi: 10.1111/j.1476-5381.1977.tb16750.x.

Intracerebroventricularly (i.c.v.) administered vasopressin (0.001-1.0 u) in dogs anaesthetized with chloralose produced adose-dependent increase in urine flow with a concomitant decrease in the levels of antidiuretic hormone (ADH) in jugular vein blood. 2. Higher doses of vasopressin (1.5-2.0 u, i.c.v) on the other hand had an antidiuretic effect and produced an increase in blood ADH level. 3. Pretreatment (i.c.v.) with a beta-adrenoceptor antagonist completely blocked the diuretic response of low doses of vasopressin (i.c.v.) but did not influence the antidiuretic response obtained with high doses. 4. Repeated administration of vasopressin (1.0 u, i.c.v.) induced tachyphylaxis; central catecholamine depletion with tetrabenazine significantly inhibited the vasopressin-induced diuretic response. 5. It is concluded that intracerebroventricular vasopressin-induced changes in ADH secretion are mediated through the release of catecholamines in the central nervous system.

用氯醛糖麻醉的犬，脑室内（i.c.v.）注射血管加压素（0.001 - 1.0单位）会使尿流量呈剂量依赖性增加，同时颈静脉血中抗利尿激素（ADH）水平降低。2. 另一方面，较高剂量的血管加压素（1.5 - 2.0单位，i.c.v.）具有抗利尿作用，并使血液中ADH水平升高。3. 用β-肾上腺素能受体拮抗剂进行预处理（i.c.v.）可完全阻断低剂量血管加压素（i.c.v.）的利尿反应，但不影响高剂量血管加压素的抗利尿反应。4. 重复注射血管加压素（1.0单位，i.c.v.）会引起快速耐受性；用丁苯那嗪使中枢儿茶酚胺耗竭可显著抑制血管加压素诱导的利尿反应。5. 得出的结论是，脑室内血管加压素诱导的ADH分泌变化是通过中枢神经系统中儿茶酚胺的释放介导的。

Bhargava K P, Kulshrestha V K, Srivastava Y P

Br J Pharmacol. 1977 May;60(1):77-81. doi: 10.1111/j.1476-5381.1977.tb16750.x.

Intracerebroventricularly (i.c.v.) administered vasopressin (0.001-1.0 u) in dogs anaesthetized with chloralose produced adose-dependent increase in urine flow with a concomitant decrease in the levels of antidiuretic hormone (ADH) in jugular vein blood. 2. Higher doses of vasopressin (1.5-2.0 u, i.c.v) on the other hand had an antidiuretic effect and produced an increase in blood ADH level. 3. Pretreatment (i.c.v.) with a beta-adrenoceptor antagonist completely blocked the diuretic response of low doses of vasopressin (i.c.v.) but did not influence the antidiuretic response obtained with high doses. 4. Repeated administration of vasopressin (1.0 u, i.c.v.) induced tachyphylaxis; central catecholamine depletion with tetrabenazine significantly inhibited the vasopressin-induced diuretic response. 5. It is concluded that intracerebroventricular vasopressin-induced changes in ADH secretion are mediated through the release of catecholamines in the central nervous system.

用氯醛糖麻醉的犬，脑室内（i.c.v.）注射血管加压素（0.001 - 1.0单位）会使尿流量呈剂量依赖性增加，同时颈静脉血中抗利尿激素（ADH）水平降低。2. 另一方面，较高剂量的血管加压素（1.5 - 2.0单位，i.c.v.）具有抗利尿作用，并使血液中ADH水平升高。3. 用β-肾上腺素能受体拮抗剂进行预处理（i.c.v.）可完全阻断低剂量血管加压素（i.c.v.）的利尿反应，但不影响高剂量血管加压素的抗利尿反应。4. 重复注射血管加压素（1.0单位，i.c.v.）会引起快速耐受性；用丁苯那嗪使中枢儿茶酚胺耗竭可显著抑制血管加压素诱导的利尿反应。5. 得出的结论是，脑室内血管加压素诱导的ADH分泌变化是通过中枢神经系统中儿茶酚胺的释放介导的。