Jen Wendy S, Truppo Matthew D, Amos Deborah, Devine Paul, McNevin Michael, Biba Mirlinda, Campos Kevin R
Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.
Org Lett. 2008 Mar 6;10(5):741-4. doi: 10.1021/ol7027543. Epub 2008 Feb 2.
Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2-diarylethanes via an unusual Cu(I)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%.
在此，我们报道了通过一种不寻常的铜（I）催化二聚反应实现1,2 - 二吡啶基 - 1,2 - 二芳基乙烷的不对称合成。将多种对映体富集的取代2 - 吡啶醇进行一锅法反应，可高产率、非对映选择性地生成所需产物，对映体过量值高达>99%。
