关于钐/六甲基磷酰胺在二碘化钐还原反应中电子转移后步骤中的作用。
On the role of samarium/HMPA in the post electron-transfer steps in SmI2 reductions.
作者信息
Farran Hani, Hoz Shmaryahu
机构信息
Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
出版信息
Org Lett. 2008 Mar 6;10(5):865-7. doi: 10.1021/ol7029883. Epub 2008 Feb 2.
PMID:18247497
Abstract
The reaction of p,p'-dichlorobenzophenone with SmI2 was studied in the presence of variable amounts of HMPA. The electron-transfer step takes place instantaneously. In the presence of excess substrate, the addition of HMPA retarded the rate of coupling to pinacol by a factor of 250. In the presence of an excess of SmI2, the initial rate retardation is followed by a dramatic increase in rate.
摘要
在不同量的六甲基磷酰三胺（HMPA）存在下，研究了对，对'-二氯二苯甲酮与二碘化钐（SmI₂）的反应。电子转移步骤瞬间发生。在过量底物存在下，加入HMPA使生成频哪醇的偶联速率减慢了250倍。在过量二碘化钐（SmI₂）存在下，初始速率减慢之后是速率的急剧增加。
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