Thosani Maya K, Schneck Gideon, Jones Evan C
Department of Dermatology, Stony Brook University Medical Center, Stony Brook, New York 11733, USA.
Dermatol Surg. 2008 May;34(5):585-99. doi: 10.1111/j.1524-4725.2007.34115.x. Epub 2008 Jan 31.
We present a case report of periocular squamous cell carcinoma and a review of the literature with emphasis on early diagnosis, proper follow-up and management, reconstructive options, and new immunomodulatory therapies.
The objective is to guide the dermatologist and the dermatologic surgeon in proper management and continued care of patients with periocular squamous cell carcinoma in light of its propensity for perineural involvement and regional lymphatic metastases.
A MEDLINE, Ovid, and PubMed search was conducted for recent relevant articles pertaining to "periocular,""periorbital,""squamous cell" carcinoma, and their "surgery""treatment" modalities.
Periocular squamous cell carcinoma is an aggressive tumor, characterized by perineural involvement and an overall rate of regional lymph node metastases reported to range from 10% to as high as 20% to 25%. Increased vigilance must be undertaken when treating these high-risk tumors. Mohs micrographic surgery or excision with frozen section analysis is the standard of care for periocular squamous cell carcinoma. Multiple options exist for the reconstruction of the postoperative defect that allow for excellent function and cosmesis. Finally, research into new immunomodulators will hopefully lead to an increased understanding of the aggressive nature of periocular squamous cell carcinoma and potential aid in the treatment of the tumor.
我们报告一例眼周鳞状细胞癌病例，并对文献进行综述，重点关注早期诊断、恰当的随访与管理、重建方案以及新的免疫调节疗法。
鉴于眼周鳞状细胞癌有神经周围侵犯和区域淋巴结转移的倾向，旨在指导皮肤科医生和皮肤科外科医生对眼周鳞状细胞癌患者进行恰当的管理和持续护理。
在MEDLINE、Ovid和PubMed数据库中检索近期与“眼周”“眶周”“鳞状细胞”癌及其“手术”“治疗”方式相关的文章。
眼周鳞状细胞癌是一种侵袭性肿瘤，其特征为神经周围侵犯，区域淋巴结转移的总体发生率据报道在10%至高达20%至25%之间。治疗这些高危肿瘤时必须提高警惕。莫氏显微外科手术或切除加冰冻切片分析是眼周鳞状细胞癌的标准治疗方法。术后缺损的重建有多种选择，可实现良好的功能和美容效果。最后，对新免疫调节剂的研究有望增进对眼周鳞状细胞癌侵袭性本质的理解，并可能有助于肿瘤治疗。
