Rocha B, Vassalli P, Guy-Grand D
Unités INSERM *U25, UA CNRS 122, Geneva, Switzerland.
J Exp Med. 1991 Feb 1;173(2):483-6. doi: 10.1084/jem.173.2.483.
Gut intraepithelial lymphocytes (IEL) contain two independent T cell receptor alpha/beta + T cell populations, with different V beta repertoires. In DBA/2 mice (Mlsa, IE+), the CD4+ and heterodimeric alpha/beta CD8+ thymodependent T cell pool shows the same deletion of V beta 6, 8.1, and 11+ cells as found in peripheral lymphoid organs. In contrast, such deletions are not observed in the pool of IEL bearing homodimeric alpha CD8+ chains, in which these V beta families are frequently observed in high amounts. The size of this gut homodimeric alpha CD8+ IEL pool and its different V beta repertoire selection demonstrate the existence of a major extrathymic pathway of T cell differentiation with a gut-restricted localization. The large amount of the thymo-independent, homodimeric alpha CD8+ IEL found in the small bowel may contribute to a first line of defense against exogenous superantigens.
肠道上皮内淋巴细胞（IEL）包含两个独立的T细胞受体α/β+ T细胞群体，其Vβ库不同。在DBA/2小鼠（Mlsa，IE+）中，CD4+和异二聚体α/β CD8+胸腺依赖性T细胞库显示出与外周淋巴器官中相同的Vβ6、8.1和11+细胞缺失。相比之下，在携带同二聚体α CD8+链的IEL库中未观察到这种缺失，在该库中这些Vβ家族经常大量出现。这种肠道同二聚体α CD8+ IEL库的大小及其不同的Vβ库选择证明存在一条主要的胸腺外T细胞分化途径，其定位局限于肠道。在小肠中发现的大量非胸腺依赖性、同二聚体α CD8+ IEL可能有助于对外源超抗原的第一道防线。
