两种核组蛋白激酶酶活性的细胞周期依赖性
Cell-cycle dependence of two nuclear histone kinase enzyme activities.
作者信息
Hardie D G, Matthews H R, Bradbury E M
出版信息
Eur J Biochem. 1976 Jun 15;66(1):37-42. doi: 10.1111/j.1432-1033.1976.tb10422.x.
Abstract
Growth-associated histone kinases have been extracted from Physarum polycephalum nuclei and resolved into two components by ion-exchange chromatography. The two component activities have different substrate specificities and different times of appearance in the cell cycle. It is proposed that the enzyme(s) phosphorylate H1 histone in vivo in G2 phase, possibly sequentially in time at different sites in the H1 amino acid sequence.
摘要
已从多头绒泡菌细胞核中提取出与生长相关的组蛋白激酶，并通过离子交换色谱法将其分离为两个组分。这两种组分的活性具有不同的底物特异性，且在细胞周期中出现的时间不同。有人提出，该酶（或这些酶）在体内G2期使H1组蛋白磷酸化，可能是在H1氨基酸序列的不同位点按时间顺序依次进行。
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