生殖细胞系的表观遗传编程：内分泌干扰物对跨代疾病发展的影响。
Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease.
作者信息
Anway Matthew D, Skinner Michael K
机构信息
Centre for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA.
出版信息
Reprod Biomed Online. 2008 Jan;16(1):23-5. doi: 10.1016/s1472-6483(10)60553-6.
Abstract
Epigenetic programming of the germ line occurs during embryonic development in a sex-specific manner. The male germ line becomes imprinted following sex determination. Environmental influences can alter this epigenetic programming and affect not only the developing offspring, but also potentially subsequent generations. Exposure to an endocrine disruptor (i.e. vinclozolin) during embryonic gonadal sex determination can alter the male germ-line epigenetics (e.g. DNA methylation). The epigenetic mechanism involves the alteration of DNA methylation in the germ line that appears to transmit transgenerational adult onset disease, including spermatogenic defects, prostate disease, kidney disease and cancer.
摘要
生殖细胞系的表观遗传编程在胚胎发育过程中以性别特异性方式发生。雄性生殖细胞系在性别决定后会被印记。环境影响可改变这种表观遗传编程，不仅会影响发育中的后代，还可能影响后续世代。在胚胎性腺性别决定期间接触内分泌干扰物（如乙烯菌核利）可改变雄性生殖细胞系的表观遗传学（如DNA甲基化）。表观遗传机制涉及生殖细胞系中DNA甲基化的改变，这种改变似乎会传递跨代的成年期疾病，包括生精缺陷、前列腺疾病、肾脏疾病和癌症。
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