Wang Jing, Sun Xiguang, Yang Zongxing, Li Sijie, Wang Yufeng, Ren Ruoxue, Liu Ziyue, Yu Dehai
Department of Reproductive Medicine, Department of Prenatal Diagnosis, Changchun, China.
Hand Surgery Department, Changchun, China.
Front Physiol. 2023 Jan 4;13:998424. doi: 10.3389/fphys.2022.998424. eCollection 2022.
Premature ovarian failure (POF), or premature ovarian insufficiency (POI), is a multifactorial and heterogeneous disease characterized by amenorrhea, decreased estrogen levels and increased female gonadotropin levels. The incidence of POF is increasing annually, and POF has become one of the main causes of infertility in women of childbearing age. The etiology and pathogenesis of POF are complex and have not yet been clearly elucidated. In addition to genetic factors, an increasing number of studies have revealed that epigenetic changes play an important role in the occurrence and development of POF. However, we found that very few papers have summarized epigenetic variations in POF, and a systematic analysis of this topic is therefore necessary. In this article, by reviewing and analyzing the most relevant literature in this research field, we expound on the relationship between DNA methylation, histone modification and non-coding RNA expression and the development of POF. We also analyzed how environmental factors affect POF through epigenetic modulation. Additionally, we discuss potential epigenetic biomarkers and epigenetic treatment targets for POF. We anticipate that our paper may provide new therapeutic clues for improving ovarian function and maintaining fertility in POF patients.
卵巢早衰（POF），或卵巢储备功能减退（POI），是一种多因素且异质性的疾病，其特征为闭经、雌激素水平降低以及女性促性腺激素水平升高。POF的发病率逐年上升，已成为育龄期女性不孕的主要原因之一。POF的病因和发病机制复杂，尚未完全阐明。除遗传因素外，越来越多的研究表明，表观遗传变化在POF的发生发展中起重要作用。然而，我们发现很少有论文总结POF中的表观遗传变异，因此有必要对该主题进行系统分析。在本文中，通过回顾和分析该研究领域最相关的文献，我们阐述了DNA甲基化、组蛋白修饰和非编码RNA表达与POF发生发展之间的关系。我们还分析了环境因素如何通过表观遗传调控影响POF。此外，我们讨论了POF潜在的表观遗传生物标志物和表观遗传治疗靶点。我们预计我们的论文可能为改善POF患者的卵巢功能和维持生育能力提供新的治疗线索。
