Bronzino P, Colombini M, Ferro A, Gambetta G, Gennaro M, Ivaldi L, Revetria P
Ospedale dei Poveri Infermi (Località S Bernardino), Ceva Struttura Complessa Chirurgia Generale, Italy.
G Chir. 2008 Jan-Feb;29(1-2):33-7.
The Authors describe four cases of gastrointestinal stromal tumours (GIST) two of them were localized in the stomach, the others in the ileum. GIST are neoplasms of mesenchymal origin which develop inside the wall of the digestive tract. The most frequent site is the stomach, followed by the small bowel; less commonly these tumors can affect the oesophagus, the colon and the rectum. GIST originate from precursors of the interstitial cells of Cajal, which are localized in the gastro-intestinal wall and are involved in the regulation of the peristalsis. The treatment is surgical resection. For advanced disease there is a new interesting treatment based on the imatinib, a tyrosine kinase inhibitor.
作者描述了4例胃肠道间质瘤（GIST），其中2例位于胃，其余位于回肠。GIST是起源于间充质的肿瘤，发生于消化道壁内。最常见的部位是胃，其次是小肠；这些肿瘤较少累及食管、结肠和直肠。GIST起源于位于胃肠壁内的Cajal间质细胞前体，这些细胞参与蠕动调节。治疗方法是手术切除。对于晚期疾病，有一种基于伊马替尼（一种酪氨酸激酶抑制剂）的新型有趣治疗方法。
