Li Hongqi, Song Yanxi, Peng Xianfu
Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, PR China.
Steroids. 2008 May;73(5):488-94. doi: 10.1016/j.steroids.2007.12.024. Epub 2007 Dec 28.
Preparative chemical methods for the synthesis of 10 degradation or photodecomposition products of mestranol and ethinyl estradiol (EE) are described. The synthesized compounds are useful as reference materials and standards for pharmaceutical analysis of mestranol and EE as bulk chemical or in formulated product. New synthetic methods were presented and the known synthetic procedures were improved. Detailed structural characterization of the degradation or photodecomposition products of mestranol and EE and related compounds was reported.
本文描述了用于合成炔雌醇和炔雌醇（EE）的10种降解或光解产物的制备化学方法。合成的化合物可用作炔雌醇和EE原料药或制剂产品药物分析的参考物质和标准品。提出了新的合成方法并改进了已知的合成程序。报告了炔雌醇和EE及其相关化合物降解或光解产物的详细结构表征。
