芳基磺酰胺CB2受体激动剂：构效关系及CB2选择性的优化
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
作者信息
Ermann Monika, Riether Doris, Walker Edward R, Mushi Innocent F, Jenkins James E, Noya-Marino Beatriz, Brewer Mark L, Taylor Malcolm G, Amouzegh Patricia, East Stephen P, Dymock Brian W, Gemkow Mark J, Kahrs Andreas F, Ebneth Andreas, Löbbe Sabine, O'Shea Kathy, Shih Daw-Tsun, Thomson David
机构信息
Evotec (UK) Ltd., 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, United Kingdom.
出版信息
Bioorg Med Chem Lett. 2008 Mar 1;18(5):1725-9. doi: 10.1016/j.bmcl.2008.01.042. Epub 2008 Jan 18.
A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.
一次高通量筛选活动导致发现了一种高效的大麻素受体1（CB1）和2（CB2）双重激动剂。在进行全面的构效关系探索后，确定了一系列选择性CB2完全激动剂。
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