Kapil Sanjay, Allison Robin W, Johnston Larry, Murray Brandy L, Holland Steven, Meinkoth Jim, Johnson Bill
Oklahoma Animal Disease Diagnostic Laboratory, Center for Veterinary Health Sciences, Farm and Ridge Road, Stillwater, OK 74078, USA.
Clin Vaccine Immunol. 2008 Apr;15(4):707-12. doi: 10.1128/CVI.00005-08. Epub 2008 Feb 6.
Canine distemper virus (CDV) is a highly contagious virus that causes multisystemic disease in dogs. We received seven samples from dogs with CD from the United States during 2007. CDV isolates from these samples formed large, multinucleated syncytia in a Vero cell line expressing canine signaling lymphocyte activation molecule (SLAM). Based on the hemagglutinin gene sequences, the CDV isolates from three states (California, Missouri, and Oklahoma) formed two CDV genetic groups: group I (major; six of seven isolates) consisted of CDV isolates closely related to the European wildlife lineage of CDV, and group II (minor; one of seven isolates) was genetically related to the Arctic-like lineage of CDV. However, both CDV groups were genetically different from the current vaccine strains that belong to the American-1 lineage of the old (1930 to 1950) CDV isolates.
犬瘟热病毒(CDV)是一种高度传染性病毒,可导致犬类多系统疾病。2007年期间,我们从美国患有犬瘟热的犬只中收到了7份样本。这些样本中的CDV分离株在表达犬信号淋巴细胞激活分子(SLAM)的Vero细胞系中形成了大型多核合胞体。基于血凝素基因序列,来自三个州(加利福尼亚州、密苏里州和俄克拉何马州)的CDV分离株形成了两个CDV遗传组:第一组(主要;7个分离株中的6个)由与CDV欧洲野生动物谱系密切相关的CDV分离株组成,第二组(次要;7个分离株中的1个)在基因上与CDV北极样谱系相关。然而,这两个CDV组在基因上均与属于旧的(1930年至1950年)CDV分离株美国-1谱系的当前疫苗株不同。