Lanszki Zsófia, Zana Brigitta, Zeghbib Safia, Jakab Ferenc, Szabó Nikoletta, Kemenesi Gábor
National Laboratory of Virology, Szentágothai Research Centre, University of Pécs, H-7624 Pécs, Hungary.
Institute of Biology, Faculty of Sciences, University of Pécs, H-7624 Pécs, Hungary.
Vet Sci. 2021 Apr 11;8(4):61. doi: 10.3390/vetsci8040061.
Canine distemper virus (CDV) is a major viral pathogen in domestic dogs, belonging to the family, in the genus. It is present worldwide, and a wide range of domestic animals and wild carnivores are at risk. In the absence of vaccination, dogs have a low chance of survival; however, if and when a dog survives, it can take an average of a few weeks to a few months to fully wipe out the virus. In the present study, we traced the course of infection of a 1-year-old mixed-breed male dog. The animal had an unusually long course of persistent CDV infection with a vector-borne heartworm () co-infection. The dog excreted the CDV for 17 months with PCR positivity in urine samples collected from February 2019 through June 2020. The sequencing and phylogenetic analysis of the hemagglutinin gene revealed the CDV to be the member of the endemic Arctic-like genetic lineage. To the best of our knowledge, this report represents the longest documented canine infection of CDV. Notably, we highlight the necessity regarding CDV infectivity studies to better comprehend the transmission attributes of the virus.
犬瘟热病毒（CDV）是家犬中的一种主要病毒病原体，属于 科 属。它在全球范围内存在，多种家畜和野生食肉动物都有感染风险。在未接种疫苗的情况下，犬类存活几率较低；然而，如果犬类存活下来，平均需要数周至数月才能完全清除病毒。在本研究中，我们追踪了一只1岁混种雄性犬的感染过程。该动物患有持续时间异常长的犬瘟热病毒持续性感染，并伴有媒介传播的心丝虫（ ）共同感染。从2019年2月至2020年6月采集的尿液样本中，该犬排出犬瘟热病毒达17个月，PCR检测呈阳性。血凝素基因的测序和系统发育分析显示，该犬瘟热病毒属于地方性北极样遗传谱系成员。据我们所知，本报告是有记录以来犬瘟热病毒感染时间最长的病例。值得注意的是，我们强调了进行犬瘟热病毒感染性研究以更好理解该病毒传播特性的必要性。
