Stewart Jesse C, Janicki-Deverts Denise, Muldoon Matthew F, Kamarck Thomas W
Department of Psychology, Indiana University-Purdue University Indianapolis, 402 North Blackford Street, LD 100E, Indianapolis, IN 46202, USA.
Psychosom Med. 2008 Feb;70(2):197-204. doi: 10.1097/PSY.0b013e3181642a0b. Epub 2008 Feb 6.
Recent evidence suggests that depressive symptoms and hostility may act together, as interacting factors, to have an effect on the circulating levels of inflammatory markers relevant to coronary artery disease. Further research, however, is needed to clarify the nature of this interaction and to determine whether previous findings extend to older adults. In this report we examined the cross-sectional associations of depressive symptoms, hostility, and their interaction with circulating levels of two such inflammatory markers-interleukin-6 (IL-6) and C-reactive protein (CRP).
A total of 316 healthy, older adults underwent a blood draw for the assessment of serum IL-6 and CRP and completed the Beck Depression Inventory-II and the Cook-Medley Hostility Scale. Regression analyses were performed to examine depressive symptoms, hostility, and their interaction as predictors of serum IL-6 and CRP.
After adjustment for demographic factors, cardiovascular risk factors, and health behaviors, we detected depressive symptoms x hostility interactions for serum IL-6 (DeltaR(2) = .027, p < .01) and CRP (DeltaR(2) = .015, p < .05). Simple slope analyses revealed that hostility was positively related to serum IL-6 only among individuals with higher depressive symptoms. The pattern of results was similar for serum CRP, although none of the simple slopes was significant.
Our findings suggest that depressive symptoms may moderate the hostility-inflammation relationship such that hostility may augment inflammatory processes relevant to coronary artery disease only in the presence of depressive symptoms. Our results also extend previous findings from younger adults to older adults from the general community.
最近有证据表明，抑郁症状和敌意可能共同作为相互作用的因素，影响与冠状动脉疾病相关的炎症标志物的循环水平。然而，需要进一步研究来阐明这种相互作用的本质，并确定先前的研究结果是否适用于老年人。在本报告中，我们研究了抑郁症状、敌意及其相互作用与两种此类炎症标志物——白细胞介素-6（IL-6）和C反应蛋白（CRP）的循环水平之间的横断面关联。
共有316名健康的老年人接受了血液检测以评估血清IL-6和CRP，并完成了贝克抑郁量表第二版和库克-梅德利敌意量表。进行回归分析以检验抑郁症状、敌意及其相互作用作为血清IL-6和CRP预测指标的情况。
在对人口统计学因素、心血管危险因素和健康行为进行调整后，我们发现血清IL-6（ΔR² = 0.027，p < 0.01）和CRP（ΔR² = 0.015，p < 0.05）存在抑郁症状×敌意的相互作用。简单斜率分析显示，仅在抑郁症状较高的个体中，敌意与血清IL-6呈正相关。血清CRP的结果模式相似，尽管所有简单斜率均无统计学意义。
我们的研究结果表明，抑郁症状可能会调节敌意与炎症的关系，使得只有在存在抑郁症状的情况下，敌意才可能增强与冠状动脉疾病相关的炎症过程。我们的结果也将先前在年轻人中的研究结果扩展到了普通社区的老年人。
