• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The small nuclear ribonucleoproteins, SmB and B', are products of a single gene.

作者信息

Chu J L, Elkon K B

机构信息

Hospital for Special Surgery, Cornell University Medical Center, New York, NY 10021.

出版信息

Gene. 1991 Jan 15;97(2):311-2. doi: 10.1016/0378-1119(91)90069-n.

DOI:10.1016/0378-1119(91)90069-n
PMID:1825643
Abstract

Nucleotide sequencing of HeLa genomic DNA amplified by the polymerase chain reaction revealed 696-bp and 841-bp introns within the gene encoding the proteins SmB and SmB', respectively. Since splice consensus sequences were observed flanking the 145-bp insertion detected in the cDNA encoding SmB, we conclude that SmB and SmB' are derived from alternative splicing of a single gene transcript.

摘要

相似文献

1
The small nuclear ribonucleoproteins, SmB and B', are products of a single gene.
Gene. 1991 Jan 15;97(2):311-2. doi: 10.1016/0378-1119(91)90069-n.
2
Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction.通过聚合酶链反应获得的重组人宫颈癌细胞系HeLa SmB和B'肽的表位作图。
J Immunol. 1990 Jul 15;145(2):636-43.
3
Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci.重复的SNRPB'/B和SNRPN基因座的协同调控与分子进化
Nucleic Acids Res. 1999 Dec 1;27(23):4577-84. doi: 10.1093/nar/27.23.4577.
4
Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'.
Biochem Biophys Res Commun. 2001 Aug 3;285(5):1206-12. doi: 10.1006/bbrc.2001.5302.
5
Enhanced transcription of the gene encoding the SmN autoantigen in patients with systemic lupus erythematosus does not result in enhanced levels of the SmN protein.
Autoimmunity. 1994;19(2):81-7. doi: 10.3109/08916939409009535.
6
The intronless mouse gene for the tissue specific splicing protein SmN is a processed pseudogene containing a stop codon after thirty-one amino acids.组织特异性剪接蛋白SmN的无内含子小鼠基因是一个加工过的假基因，在31个氨基酸后含有一个终止密码子。
DNA Seq. 1992;2(4):241-6. doi: 10.3109/10425179209020809.
7
Analysis of genes for human snRNP Sm-D1 protein and identification of the promoter sequence which shows segmental homology to the promoters of Sm-E and U1 snRNA genes.人类小核核糖核蛋白Sm-D1蛋白基因分析及与Sm-E和U1小核RNA基因启动子具有片段同源性的启动子序列鉴定。
Gene. 1997 Apr 21;189(2):245-54. doi: 10.1016/s0378-1119(96)00858-x.
8
The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons.编码小核核糖核蛋白相关蛋白N的基因在神经元中高水平表达。
J Biol Chem. 1992 Apr 25;267(12):8521-9.
9
Expression of the tissue specific splicing protein SmN in neuronal cell lines and in regions of the brain with different splicing capacities.
Brain Res Mol Brain Res. 1992 Nov;16(1-2):13-9. doi: 10.1016/0169-328x(92)90188-h.
10
Peptide mimics of a major lupus epitope of SmB/B'.SmB/B'主要狼疮表位的肽模拟物
Ann N Y Acad Sci. 2003 Apr;987:215-29. doi: 10.1111/j.1749-6632.2003.tb06051.x.

引用本文的文献

1
Spatial regulation of cytoplasmic snRNP assembly at the cellular level.细胞水平上细胞质小核核糖核蛋白组装的空间调控。
J Exp Bot. 2015 Dec;66(22):7019-30. doi: 10.1093/jxb/erv399. Epub 2015 Aug 27.
2
Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.U1-70k 调控亚基在人剪接体 U1 snRNP 中的构象变化。
PLoS One. 2009 Sep 28;4(9):e7202. doi: 10.1371/journal.pone.0007202.
3
The assembly of a spliceosomal small nuclear ribonucleoprotein particle.剪接体小核核糖核蛋白颗粒的组装。
Nucleic Acids Res. 2008 Nov;36(20):6482-93. doi: 10.1093/nar/gkn658. Epub 2008 Oct 14.
4
Evolutionary diversification of the Sm family of RNA-associated proteins.RNA相关蛋白Sm家族的进化多样化。
Mol Biol Evol. 2008 Nov;25(11):2255-67. doi: 10.1093/molbev/msn175. Epub 2008 Aug 7.
5
Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.Sm蛋白和Sm样蛋白组装成两个具有深远进化起源的相关复合物。
EMBO J. 1999 Jun 15;18(12):3451-62. doi: 10.1093/emboj/18.12.3451.
6
The snRNP core assembly pathway: identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro.小核核糖核蛋白核心组装途径：体外稳定核心蛋白异源复合物和小核核糖核蛋白亚核心颗粒的鉴定。
EMBO J. 1996 May 1;15(9):2256-69.
7
New nucleotide sequence data on the EMBL File Server.欧洲分子生物学实验室文件服务器上的新核苷酸序列数据。
Nucleic Acids Res. 1991 Jun 25;19(12):3467-82. doi: 10.1093/nar/19.12.3467.
8
B-cell epitopes of Sm autoantigens.Sm自身抗原的B细胞表位
Mol Biol Rep. 1992 Jun;16(3):165-74. doi: 10.1007/BF00464704.