丙酸睾酮对支持细胞分泌功能的双相效应。

Biphasic effect of testosterone propionate on Sertoli cell secretory function.

作者信息

Weddington S C, Hansson V, Purvis K, Varaas T, Verjans H L, Eik-Nes K B, Ryan W H, French F S, Ritzen E M

出版信息

Mol Cell Endocrinol. 1976 Jun-Jul;5(1-2):137-45. doi: 10.1016/0303-7207(76)90076-9.

Abstract

When various doses of testosterone propionate (10 to 10,000 mug/day) were given to 21-day-old rats for 10 days a biphasic effect was seen both on testis weight and production of androgen-binding protein (ABP). At low doses (10 to 100 mug testosterone propionate/day) there was a reduction in testis weight as well as ABP content in the epididymis. At higher doses of testosterone propionate, there was a stimulation of both testicular weight and ABP production in spite of suppressed serum FSH and LH levels. These effects of testosterone propionate on Sertoli cell secretory function strongly suggest that the Sertoli cell is a target cell for androgen.

摘要

当给21日龄的大鼠每天注射不同剂量的丙酸睾酮（10至10,000微克/天），持续10天时，观察到对睾丸重量和雄激素结合蛋白（ABP）产生的双相效应。低剂量（每天10至100微克丙酸睾酮）时，睾丸重量以及附睾中ABP含量降低。尽管血清促卵泡激素（FSH）和促黄体生成素（LH）水平受到抑制，但在较高剂量的丙酸睾酮作用下，睾丸重量和ABP产生均受到刺激。丙酸睾酮对支持细胞分泌功能的这些作用强烈表明，支持细胞是雄激素的靶细胞。