Pasquali Ricardo C, Taurozzi Melina P, Bregni Carlos
Cátedra de Farmacotecnia I, Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 6o piso, 1113 Buenos Aires, Argentina.
Int J Pharm. 2008 May 22;356(1-2):44-51. doi: 10.1016/j.ijpharm.2007.12.034. Epub 2008 Jan 3.
The methods and results obtained by Griffin et al. in the determination of the hydrophilic-lipophilic balance (HLB) values of non-ionic surfactants and of required HLB values of oil mixtures are reviewed in the present work. HLB values published by Griffin were compared with those obtained by calculations from theoretic chemical formulas. Griffin HLB values of polyoxyethylene alkyl ethers, polyoxyethylene monoesters and propylene glycol monoesters coincide with those obtained from such theoretical chemical formulations. These results demonstrate that, for these surfactants, Griffin did not experimentally obtain their HLB values, but instead calculated them from theoretic formulae. For the calculation of the HLB values of glycerol monostearate, sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters, Griffin's assumptions were possibly based upon the mean saponification values of the ester and the acid of the fatty acid. It is concluded that the HLB values of non-ionic surfactants were not rigorously defined. Moreover, Griffin could not demonstrate the validity of the assumption that individual required HLB values can be added up to obtain the overall required HLB value of an oil mixture. The HLB and required HLB values published by Griffin should only be taken as approximate guidelines.
本工作综述了格里芬等人在测定非离子表面活性剂的亲水亲油平衡（HLB）值以及油混合物所需HLB值方面所采用的方法和获得的结果。将格里芬公布的HLB值与通过理论化学公式计算得到的值进行了比较。聚氧乙烯烷基醚、聚氧乙烯单酯和丙二醇单酯的格里芬HLB值与从这类理论化学公式得到的值相符。这些结果表明，对于这些表面活性剂，格里芬并非通过实验获得其HLB值，而是从理论公式计算得出。对于单硬脂酸甘油酯、脱水山梨醇脂肪酸酯和聚氧乙烯脱水山梨醇脂肪酸酯的HLB值计算，格里芬的假设可能基于脂肪酸酯和酸的平均皂化值。得出的结论是非离子表面活性剂的HLB值没有得到严格定义。此外，格里芬无法证明单个所需HLB值可以相加得到油混合物的总体所需HLB值这一假设的有效性。格里芬公布的HLB值和所需HLB值仅应被视为近似指导。
