双种族人群中的抗炎药物与认知衰退
Anti-inflammatory agents and cognitive decline in a bi-racial population.
作者信息
Grodstein Francine, Skarupski Kimberly A, Bienias Julia L, Wilson Robert S, Bennett David A, Evans Denis A
机构信息
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
出版信息
Neuroepidemiology. 2008;30(1):45-50. doi: 10.1159/000115749. Epub 2008 Feb 7.
In a prospective study among 4,409 subjects aged 65+ years, we assessed the relation of nonsteroidal anti-inflammatory agents (NSAIDs) to cognition. The main outcome was decline in global cognitive function, determined by average performance across four cognitive tests, over up to four interviews. We found similar rates of cognitive decline among recent users of aspirin and of other NSAIDs (largely ibuprofen) compared to those who did not use these NSAIDs. For lifetime duration of aspirin use, we failed to find an association with cognitive decline. However, for other NSAIDs, increasing duration of lifetime use was related to slower rates of cognitive decline, relative to no use of other NSAIDs (5+ years vs. no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.
在一项针对4409名65岁及以上受试者的前瞻性研究中，我们评估了非甾体抗炎药（NSAIDs）与认知功能之间的关系。主要结局是通过四次认知测试的平均表现来确定的整体认知功能下降，该评估持续了多达四次访谈。我们发现，与未使用这些非甾体抗炎药的人相比，近期使用阿司匹林和其他非甾体抗炎药（主要是布洛芬）的人认知功能下降的发生率相似。就阿司匹林的终生使用时长而言，我们未发现其与认知功能下降之间存在关联。然而，对于其他非甾体抗炎药，与未使用其他非甾体抗炎药相比，终生使用时长增加与认知功能下降速度较慢有关（使用5年以上与未使用：平均差异=0.12；p趋势=0.03）。总体而言，我们发现规律使用阿司匹林与认知功能下降之间没有关系，但长期使用布洛芬可能与老年人认知功能下降速度降低有关。
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