Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina, Suite 1028, Chicago, IL 60612, USA.
Curr Alzheimer Res. 2012 Jul;9(6):628-45. doi: 10.2174/156720512801322573.
The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer's disease (AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected postmortem data.
(1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate to death; (2) examine the relation of risk factors to clinical outcomes; (3) examine the relation of risk factors to measures of neuropathology; and (4) summarize additional study findings. We then discuss and contextualize the study findings.
宗教秩序研究是一项关于衰老和阿尔茨海默病（AD）的纵向临床病理队列研究。在本文中，我们总结了研究方法，包括研究设计，并描述了临床评估、风险因素评估、生前生物标本采集、脑尸检和选定的死后数据收集。
（1）审查神经病理指标与接近死亡时的临床诊断和认知之间的关系；（2）检查风险因素与临床结果之间的关系；（3）检查风险因素与神经病理学测量之间的关系；（4）总结其他研究发现。然后我们讨论并将研究结果置于上下文中。
