表皮生长因子受体家族：驱动靶向治疗的生物学机制
The epidermal growth factor receptor family: biology driving targeted therapeutics.
作者信息
Wieduwilt M J, Moasser M M
机构信息
Department of Medicine, Comprehensive Cancer Center, University of California-San Francisco, San Francisco, CA 94143-0875, USA.
出版信息
Cell Mol Life Sci. 2008 May;65(10):1566-84. doi: 10.1007/s00018-008-7440-8.
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors carry out both redundant and restricted functions in mammalian development and in the maintenance of tissues in the adult mammal. Loss of regulation of the ErbB receptors underlies many human diseases, most notably cancer. Our understanding of the function and complex regulation of these receptors has fueled the development of targeted therapeutic agents for human malignancies in the last 15 years. Here we review the biology of ErbB receptors, including their structure, signaling, regulation, and roles in development and disease, then briefly touch on their increasing roles as targets for cancer therapy.
受体酪氨酸激酶的表皮生长因子家族（ErbBs）在调节细胞增殖、存活、分化和迁移中发挥着重要作用。ErbB受体在哺乳动物发育以及成年哺乳动物组织维持过程中发挥着冗余和受限的功能。ErbB受体调控的缺失是许多人类疾病的基础，最显著的是癌症。在过去15年里，我们对这些受体功能和复杂调控的理解推动了针对人类恶性肿瘤的靶向治疗药物的发展。在这里，我们综述ErbB受体的生物学特性，包括其结构、信号传导、调控以及在发育和疾病中的作用，然后简要介绍它们作为癌症治疗靶点日益增加的作用。
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