Ghumare Santosh S, Cunningham Joan E
Survey Research Unit, College of Health Professions, The Medical University of South Carolina, Charleston, SC 29425, USA
Asian Pac J Cancer Prev. 2007 Oct-Dec;8(4):507-12.
As developing nations such as India become increasingly Westernized, incidence rates will increase for many cancers. Presently, breast cancer is the leading cancer site in female residents of India, but rates are considerably lower than in Western countries. Trends observed in Indian immigrants to the West may help predict changes expected in India.
Data were obtained from Indian cancer registries, the SEER program in the USA, IARC scientific database, and published studies. Incidence, age at diagnosis, stage at diagnosis, and hormone receptor status in these three populations were compared for the period 1993-1999.
Age-adjusted (to world standard population) incidence rates (per 100,000) in Indian immigrants (47.0-61.0) were higher than in Indian residents (7.2-33.4) but lower than in Western whites (83.1-112.0). Compared to Indian residents, Indian immigrant cases tended to be older (49 years +), diagnosed at an earlier stage, and more often hormone receptor positive, sharing similarities with Western white women.
The intermediate breast cancer trends exhibited by Indian immigrants may help predict future incidence trends amongst Indian (particularly urban) residents, which have major public health implications for India as urbanization and Westernization continue. We suggest adding demographic variables to cancer registry data, and additional studies on immigrant Indian populations.
随着印度等发展中国家日益西化，许多癌症的发病率将会上升。目前，乳腺癌是印度女性居民中最主要的癌症类型，但发病率远低于西方国家。观察印度移民到西方后的趋势可能有助于预测印度预期的变化。
数据来自印度癌症登记处、美国的监测、流行病学和最终结果（SEER）计划、国际癌症研究机构（IARC）科学数据库以及已发表的研究。对这三个人群在1993 - 1999年期间的发病率、诊断年龄、诊断阶段和激素受体状态进行了比较。
印度移民的年龄调整后（以世界标准人口为参照）发病率（每10万人）（47.0 - 61.0）高于印度居民（7.2 - 33.4），但低于西方白人（83.1 - 112.0）。与印度居民相比，印度移民病例往往年龄更大（49岁及以上），诊断时处于更早阶段，且激素受体阳性的比例更高，这与西方白人女性相似。
印度移民呈现出的中间型乳腺癌趋势可能有助于预测印度（尤其是城市）居民未来的发病率趋势，随着城市化和西化的持续，这对印度具有重大的公共卫生意义。我们建议在癌症登记数据中增加人口统计学变量，并对印度移民人群进行更多研究。
