Salvadori B, Bartoli C, Zurrida S, Delledonne V, Squicciarini P, Rovini D, Barletta L
Division of Surgical Oncology C, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Eur J Cancer. 1991;27(1):35-7. doi: 10.1016/0277-5379(91)90055-i.
100 women underwent wide resection for palpable or mammographically detected breast lesions (1 woman had bilateral lesions). Histology excluded invasive cancer, but one or more foci of lobular carcinoma in situ (LCIS) were observed. There have been no recurrences in the 20 women who underwent total mastectomy. In the 12 patients who had a subsequent wide excision and the 68 who received no other treatment 5 presented with an invasive cancer in the same breast at some distance from the LCIS site (median follow-up 58 months). The (observed/expected) rate per 1000 per year is 10.3 for an untreated LCIS. LCIS is therefore a risk factor for invasive carcinoma. Nevertheless this risk does not indicate the use of mutilating procedures and a wait-and-see policy is appropriate.
100名女性因可触及或乳腺钼靶检查发现的乳腺病变接受了广泛切除术（1名女性有双侧病变）。组织学检查排除了浸润性癌，但观察到一个或多个小叶原位癌（LCIS）病灶。接受全乳房切除术的20名女性无复发情况。在随后接受广泛切除的12名患者以及未接受其他治疗的68名患者中，有5名在距LCIS部位一定距离的同侧乳房出现了浸润性癌（中位随访时间58个月）。未经治疗的LCIS每年每1000人的（观察/预期）发生率为10.3。因此，LCIS是浸润性癌的一个危险因素。然而，这种风险并不意味着要采用致残性手术，观望策略是合适的。
