Numata Munenori, Sugiyasu Kazunori, Kishida Takanori, Haraguchi Shuichi, Fujita Norifumi, Park Sun Min, Yun Young Ji, Kim Byeang Hyean, Shinkai Seiji
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka, 819-0395, Japan.
Org Biomol Chem. 2008 Feb 21;6(4):712-8. doi: 10.1039/b713354e. Epub 2008 Feb 5.
The influence of added polynucleotide on the gelation ability of nucleobase-appended organogelators was investigated. Uracil-appended cholesterol gelator formed a stable organogel in polar organic solvents such as n-butanol. It was found that the addition of the complementary polyadenylic acid (poly(A)) not only stabilizes the gel but also creates the helical structure in the original gel phase. Thymidine and thymine-appended gelators can form stable gel in apolar solvents, such as benzene, where poly(A)-lipid complex can act as a complementary template for the gelator molecules to create the fibrous composites. Based on these findings, we can conclude that self-assembling modes and gelation properties of nucleobase-appended organogelators are controllable by the addition of their complementary polynucleotide in organic solvents. We believe, therefore, that the present system can open the new paths to accelerate development of well-controlled one-dimensional molecular assembly systems, which would be indispensable for the creation of novel nanomaterials based on organic compounds.
研究了添加多核苷酸对核苷酸碱基连接的有机凝胶剂凝胶化能力的影响。尿嘧啶连接的胆固醇凝胶剂在极性有机溶剂如正丁醇中形成稳定的有机凝胶。研究发现，添加互补的聚腺苷酸（poly(A)）不仅能稳定凝胶，还能在原始凝胶相中形成螺旋结构。胸腺嘧啶和胸腺嘧啶连接的凝胶剂能在非极性溶剂如苯中形成稳定的凝胶，其中聚(A)-脂质复合物可作为凝胶剂分子的互补模板，以形成纤维状复合材料。基于这些发现，我们可以得出结论，在有机溶剂中添加互补多核苷酸可控制核苷酸碱基连接的有机凝胶剂的自组装模式和凝胶化性质。因此，我们相信，本体系可为加速开发精确可控的一维分子组装体系开辟新途径，而这对于基于有机化合物的新型纳米材料的创制必不可少。
