Koerhuis M R, Wunderink A, Nolen W A
Werkzaam als psychiater in opleiding in het Universitair Medisch Centrum Groningen. Hij is momenteel werkzaam als psychiater in opleiding bij de Dr. S. van Mesdagkliniek in Groningen.
Tijdschr Psychiatr. 2008;50(2):107-12.
Two patients with a psychotic depression showed insufficient response to pharmacotherapy and electroconvulsive therapy. The problem therefore was which alternative treatment options should be considered at this stage. On the bases of the available literature the most suitable options seemed to be clozapine, a monoamine oxidase inhibitor and lithium addition. Patient A responded well to clozapine and the condition of patient B improved during treatment with tranylcypromine, lithium and quetiapine.
两名患有精神病性抑郁症的患者对药物治疗和电休克治疗反应不足。因此问题在于在这个阶段应考虑哪些替代治疗方案。根据现有文献，最合适的方案似乎是氯氮平、一种单胺氧化酶抑制剂以及加用锂盐。患者A对氯氮平反应良好，患者B在使用反苯环丙胺、锂盐和喹硫平治疗期间病情有所改善。
