Ross Sharon A, Milner John A
Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7328, USA.
Am J Clin Nutr. 2007 Sep;86(3):s872-7. doi: 10.1093/ajcn/86.3.872S.
The importance of epigenetics in the etiology of disease, including cancer development and progression, is increasingly being recognized. However, the relevance of epigenetics to the metabolic syndrome, and how it may affect cancer, is only beginning to capture the interest of the scientific community. This review focuses on data supporting the hypothesis that, in addition to the "thrifty genotype" and "thrifty phenotype" hypotheses, diet-induced changes in "epigenetic programming" during fetal and postnatal development may precipitate the metabolic syndrome. Thus, epigenetics may bridge both the thrifty genotype and thrifty phenotype hypotheses and provide a link between genes and the environment concerning disease predisposition to metabolic syndrome and its associated diseases.
表观遗传学在包括癌症发生和发展在内的疾病病因学中的重要性日益得到认可。然而，表观遗传学与代谢综合征的相关性以及它如何影响癌症，才刚刚开始引起科学界的关注。本综述着重于支持以下假设的数据：除了“节俭基因型”和“节俭表型”假说外，胎儿期和出生后发育过程中饮食诱导的“表观遗传编程”变化可能会引发代谢综合征。因此，表观遗传学可能在节俭基因型和节俭表型假说之间架起桥梁，并在基因与环境之间提供关于代谢综合征及其相关疾病易感性的联系。
