破解聚腺苷酸化诱导翻译的密码。

Breaking the code of polyadenylation-induced translation.

作者信息

Richter Joel D

机构信息

Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.

出版信息

Cell. 2008 Feb 8;132(3):335-7. doi: 10.1016/j.cell.2008.01.024.

DOI:10.1016/j.cell.2008.01.024

PMID:18267064

Abstract

The translation of many maternal mRNAs is regulated by dynamic changes in poly(A) tail length. During maturation of Xenopus oocytes, polyadenylation is mediated by three different cis elements in the 3' untranslated region (UTR) of maternal mRNAs. In this issue, Piqué et al. (2008) explore the interplay of these elements to elucidate a combinatorial code that predicts the timing of polyadenylation and translation of maternal mRNAs.

摘要

许多母源mRNA的翻译受多聚腺苷酸（poly(A)）尾长度的动态变化调控。在非洲爪蟾卵母细胞成熟过程中，多聚腺苷酸化由母源mRNA 3'非翻译区（UTR）中的三种不同顺式元件介导。在本期中，皮克等人（2008年）探究了这些元件之间的相互作用，以阐明一种预测母源mRNA多聚腺苷酸化和翻译时间的组合密码。