Chien Yuchen, Lowe Scott W
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Cell. 2008 Feb 8;132(3):339-41. doi: 10.1016/j.cell.2008.01.022.
Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed to melanoma, suggesting a new approach for melanoma treatment.
细胞衰老限制受损细胞的增殖能力,从而作为一种内在的肿瘤抑制机制。在本期杂志中,瓦贾佩伊等人(2008年)确定胰岛素生长因子结合蛋白7(IGFBP7)为一种分泌因子,它介导正常黑素细胞中致癌性BRAF诱导的衰老。此外,IGFBP7触发已发展为黑色素瘤的细胞凋亡,提示了一种黑色素瘤治疗的新方法。