食欲素-1与亨廷顿舞蹈症的继发症状
Hypocretin-1 and secondary signs in Huntington's disease.
作者信息
Roos R A C, Aziz N A
机构信息
Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.
出版信息
Parkinsonism Relat Disord. 2007;13 Suppl 3:S387-90. doi: 10.1016/S1353-8020(08)70035-X.
Huntington's disease is characterised by unwanted movements, psychiatric disturbances and cognitive decline. Less well recognised symptoms and signs are weight loss, autonomic dysfunction and sleep disorders. In this study we focus on hypocretin-1 and hypothalamus functions. We found a reduction by about 30% in hypocretin signalling in patients with HD. However, it remains unclear whether this moderate decrease in hypocretin signalling contributes to clinical symptoms.
亨廷顿舞蹈症的特征是出现不自主运动、精神障碍和认知衰退。不太为人所知的症状和体征包括体重减轻、自主神经功能障碍和睡眠障碍。在本研究中，我们聚焦于下丘脑分泌素-1和下丘脑功能。我们发现亨廷顿舞蹈症患者的下丘脑分泌素信号传导减少了约30%。然而，目前尚不清楚下丘脑分泌素信号传导的这种适度降低是否会导致临床症状。
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