亨廷顿舞蹈症患者脑脊液中正常的下丘脑分泌素-1（食欲素-A）水平。
Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease.
作者信息
Meier Andreas, Mollenhauer Brit, Cohrs Stefan, Rodenbeck Andrea, Jordan Wolfgang, Meller Johannes, Otto Markus
机构信息
Department of Psychiatry and Psychotherapy, Sleep Disorders Center, Georg-August-University, von-Siebold-Strasse 5, 37075 Goettingen, Germany.
出版信息
Brain Res. 2005 Nov 30;1063(2):201-3. doi: 10.1016/j.brainres.2005.09.028. Epub 2005 Nov 2.
A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD.
据报道，患有亨廷顿舞蹈症（HD）的人类患者大脑及R6/2小鼠体内的下丘脑分泌素神经元出现了显著萎缩和缺失。我们纳入了10名HD患者和12名患有舞蹈症样运动障碍（非HD）的患者。HD组的所有患者以及非HD组的11名患者下丘脑分泌素-1水平均正常。因此，下丘脑分泌素-1可能无法作为HD的额外诊断标志物。
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