Chrysant S G, Chrysant C, Sadeghi M, Berlin L
Oklahoma Cardiovascular and Hypertension Center, Oklahoma City.
Cardiology. 1991;78(1):45-52. doi: 10.1159/000174764.
The open, long-term antihypertensive, hemodynamic and metabolic effects of betaxolol in combination with furosemide and minoxidil were investigated on 30 male patients with moderate to severe essential hypertension. Twenty-three patients were observed for 104 weeks, and 7 patients for 128 weeks. The patients were seen in the clinic every 4 weeks. Blood chemistries, electrocardiograms, chest x-rays and echocardiograms were done at set intervals during the study. This drug combination caused a significant and sustained decrease in arterial pressure and heart rate (p less than 0.001), a significant increase in the cardiothoracic ratio (p less than 0.05), left and right ventricular diameter in end diastole and in left ventricular mass (p less than 0.001), and had no effect on left ventricular wall thickness, interventricular septal thickness, left ventricular ejection fraction, myocardial fiber shortening or metabolic functions. Clinical side effects included hypertrichosis, weight gain and edema. We conclude: (1) Single daily administration of betaxolol, furosemide and minoxidil produced a significant and sustained antihypertensive effect. (2) It caused cardiac enlargement and increased left ventricular mass without deterioration of myocardial function. (3) The clinical significance of the latter findings is not known at present time.
对30例中重度原发性高血压男性患者研究了倍他洛尔联合呋塞米和米诺地尔的长期、开放的降压、血液动力学及代谢效应。23例患者观察了104周，7例患者观察了128周。患者每4周在门诊复诊一次。在研究期间按固定间隔进行血液化学检查、心电图、胸部X光及超声心动图检查。这种药物组合使动脉压和心率显著持续下降（p<0.001），心胸比率显著增加（p<0.05），舒张末期左、右心室直径及左心室质量显著增加（p<0.001），对左心室壁厚度、室间隔厚度、左心室射血分数、心肌纤维缩短或代谢功能无影响。临床副作用包括多毛症、体重增加和水肿。我们得出结论：（1）每日单次服用倍他洛尔、呋塞米和米诺地尔产生显著且持续的降压作用。（2）它导致心脏扩大和左心室质量增加，但心肌功能无恶化。（3）目前尚不清楚后一发现的临床意义。
