Seifert H, Wisplinghoff H, Kaasch A, Achilles K, Langhorst A, Peyerl-Hoffmann G, Woehrmann A, Fätkenheuer G, Salzberger B, Kern W V
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln, Germany.
Dtsch Med Wochenschr. 2008 Feb;133(8):340-5. doi: 10.1055/s-2008-1046715.
Staphylococcus aureus is a leading cause of bloodstream infection and S. aureus bacteremia (SAB) is one of the most severe infections acquired in hospital or in the community. The epidemiology and prognosis of this infection in Germany is not fully understood because of the lack of prospective data.
A prospective, multicenter cohort study (INSTINCT, Invasive Staphylococcus aureus Infection Cohort) was initiated to record and analyse data on patients with SAB through an internet-based documentation. Data are being obtained by specially trained personnel. Clinical variables recorded are comorbidities, risk factors, clinical course, therapy, complications and outcome. Prospectively acquired data from 1 January 2006 to 31 October 2007 are now available from two of the study centers.
During this period 263 patients with SAB were identified. 52 % of patients had hospital-acquired infections, 28 % had non-nosocomial but healthcare-associated infections, and 20 % had community-acquired infections. The mean patient age was 61 years, 38 % of patients were female. 62 % of the patients had primary bloodstream infections, while 38 % had a secondary bacteremia, diagnosed on the basis of an underlying organ infection with S. AUREUS. The mean duration of bacteremia was 3.3 days. Average duration of hospitalization was 27 days. The seven-day mortality was 8 % and in-hospital mortality 22 %.
SAB is a common infection in Germany with a serious prognosis.
金黄色葡萄球菌是血流感染的主要病因，金黄色葡萄球菌菌血症（SAB）是在医院或社区获得的最严重感染之一。由于缺乏前瞻性数据，德国这种感染的流行病学和预后情况尚未完全明了。
启动了一项前瞻性、多中心队列研究（INSTINCT，侵袭性金黄色葡萄球菌感染队列研究），通过基于互联网的文档记录和分析SAB患者的数据。数据由经过专门培训的人员获取。记录的临床变量包括合并症、危险因素、临床病程、治疗、并发症和结局。目前，两个研究中心已提供了2006年1月1日至2007年10月31日期间前瞻性获取的数据。
在此期间，共识别出263例SAB患者。52%的患者发生医院获得性感染，28%发生非医院获得性但与医疗保健相关的感染，20%发生社区获得性感染。患者的平均年龄为61岁，38%为女性。62%的患者患有原发性血流感染，38%患有继发性菌血症，后者是根据潜在的金黄色葡萄球菌器官感染诊断出来的。菌血症的平均持续时间为3.3天。平均住院时间为27天。七天死亡率为8%，住院死亡率为22%。
在德国，SAB是一种常见感染，预后严重。
