Davoudi Maryam, Mousavi-Bahar Seyed Habib, Farhanchi Afshin
Department of Anesthesiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Urol J. 2007 Fall;4(4):212-6.
The aim of this study was to investigate low-dose intrathecal meperidine for prevention or alleviation of shivering after induction of spinal anesthesia for transurethral resection of the prostate (TURP).
In a randomized controlled trial, 80 patients scheduled for TURP under spinal anesthesia were assigned into two groups of case and control. Spinal anesthesia was performed using 75 mg of hyperbaric lidocaine 5% plus meperidine, 15 mg, in the patients of the case group and the same dose of lidocaine plus normal saline in the patients of the control group. Shivering episodes were recorded during the operation and in the recovery room. Data on systolic blood pressure, heart rate, arterial oxygen saturation, and body temperature were collected before the induction of anesthesia; 5, 15, and 30 minutes after the induction; and in the recovery room.
Maximum level of sensory block was similar in the patients of the case and control groups. Shivering was not seen in the patients who received meperidine, while in the control group, 11 (27.5%) experienced some degrees of shivering (P = .001). Blood pressure, body temperature, and arterial oxygen saturation did not have a clinically significant change and they were not different between the two groups. Side effects of opioids were unremarkable.
Low-dose intrathecal meperidine is effective and safe in reducing the incidence of shivering associated with spinal anesthesia for TURP.
本研究旨在探讨低剂量鞘内注射哌替啶预防或减轻经尿道前列腺切除术（TURP）脊髓麻醉诱导后寒战的效果。
在一项随机对照试验中，80例计划在脊髓麻醉下进行TURP的患者被分为病例组和对照组。病例组患者采用75mg 5%的高压利多卡因加15mg哌替啶进行脊髓麻醉，对照组患者采用相同剂量的利多卡因加生理盐水。术中及恢复室记录寒战发作情况。在麻醉诱导前、诱导后5、15和30分钟以及恢复室收集收缩压、心率、动脉血氧饱和度和体温数据。
病例组和对照组患者的最大感觉阻滞水平相似。接受哌替啶的患者未出现寒战，而对照组有11例（27.5%）出现不同程度的寒战（P = 0.001）。血压、体温和动脉血氧饱和度无临床显著变化，两组之间也无差异。阿片类药物的副作用不明显。
低剂量鞘内注射哌替啶在降低TURP脊髓麻醉相关寒战发生率方面有效且安全。
