Department of Anesthesiology and Pain Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Korean J Anesthesiol. 2010 Dec;59(6):389-93. doi: 10.4097/kjae.2010.59.6.389. Epub 2010 Dec 31.
Shivering is a frequent event during the perioperative period. We performed a prospective, randomized, double-blind study to determine whether intrathecal meperidine (0.2 mg/kg) decreases the incidence and intensity of shivering after spinal anesthesia for transurethral operations.
Fifty patients scheduled for elective transurethral resection operations under spinal anesthesia were randomly allocated to two groups. Spinal anesthesia consisted of 0.5% hyperbaric bupivacaine 8 mg and, mperidine (0.2 mg/kg) (meperidine group) or, normal saline (saline group). Data collection, including sensory block level (by pinprick), blood pressure, heart rate, sublingual temperature, incidence and intensity of shivering, pruritus, nausea, and vomiting was performed at 10 minute intervals.
The incidence and intensity of shivering was significantly less in the meperidine group than saline group (P = 0.012 and P = 0.008, for incidence and intensity, respectively). However, pruritus was more common in the meperidine group compared with the saline group (16% vs. 0%, P < 0.05).
The addition of meperidine 0.2 mg/kg to intrathecal bupivacaine lowers the incidence and severity of shivering during transurethral prostatectomy in elderly patients.
手术期间寒战是常见的事件。我们进行了一项前瞻性、随机、双盲研究，以确定鞘内给予哌替啶（0.2mg/kg）是否会降低经尿道手术脊髓麻醉后寒战的发生率和强度。
50 名拟行择期经尿道手术的患者在脊髓麻醉下随机分为两组。脊髓麻醉由 0.5%重比重布比卡因 8mg 和哌替啶（0.2mg/kg）（哌替啶组）或生理盐水（盐水组）组成。每隔 10 分钟收集感觉阻滞水平（刺痛）、血压、心率、舌下温度、寒战、瘙痒、恶心和呕吐的发生率和强度等数据。
哌替啶组寒战的发生率和强度明显低于盐水组（发生率：P=0.012，强度：P=0.008）。然而，哌替啶组瘙痒的发生率明显高于盐水组（16%比 0%，P<0.05）。
鞘内给予 0.2mg/kg 哌替啶可降低老年患者经尿道前列腺切除术期间寒战的发生率和严重程度。
