de Valk H W, Eekhoff E M W
Universitair Medisch Centrum Utrecht, afd. Interne Geneeskunde, Utrecht.
Ned Tijdschr Geneeskd. 2008 Jan 19;152(3):121-4.
As a consequence of the increased prevalence of type 2 diabetes mellitus in younger age groups, the combination of this form of diabetes and pregnancy is seen more often. Three cases are described. A 31-year-old Caucasian woman with preconceptional type 2 diabetes mellitus presented at gestational week 8. She was receiving chronic treatment with oral hypoglycaemic drugs, and methyldopa due to the pregnancy. She was switched immediately to intensive insulin therapy, which resulted in reasonable glycaemic control. Delivery occurred prematurely at week 30 due to preeclampsia; the neonate died due to sepsis after 1 week. A 32-year-old Moroccan woman with previous gestational diabetes mellitus presented with hyperglycaemia during the first trimester, which suggested possible preconceptional type 2 diabetes mellitus. Insulin treatment was initiated, and the pregnancy continued without further consequence. A 34-year-old Moroccan woman with preconceptional type 2 diabetes mellitus was switched to intensive insulin treatment; conception was delayed until adequate glycaemic control was achieved. The pregnancy continued without further consequence. Insulin therapy should be initiated before conception in women with preconceptional type 2 diabetes mellitus that requires glucose-lowering therapy. Counselling and care are similar to that for women with type 1 diabetes mellitus. Women with a history of gestational diabetes should be counselled and tested before conception to detect silent type 2 diabetes mellitus. Given the high-risk nature oftype 2 diabetes mellitus and pregnancy, specialist team care is mandatory.
由于2型糖尿病在较年轻年龄组中的患病率增加,这种糖尿病形式与妊娠同时出现的情况更为常见。本文描述了3例病例。一名31岁的白人女性,孕前患有2型糖尿病,孕8周时就诊。她因怀孕正在接受口服降糖药和甲基多巴的长期治疗。她立即改用强化胰岛素治疗,血糖得到了合理控制。由于先兆子痫,妊娠在30周时早产;新生儿在1周后因败血症死亡。一名32岁的摩洛哥女性,既往有妊娠期糖尿病史,孕早期出现高血糖,提示可能孕前就患有2型糖尿病。开始胰岛素治疗,妊娠继续,未出现其他不良后果。一名34岁的摩洛哥女性,孕前患有2型糖尿病,改用强化胰岛素治疗;受孕推迟到血糖得到充分控制之后。妊娠继续,未出现其他不良后果。对于需要降糖治疗的孕前2型糖尿病女性,应在受孕前开始胰岛素治疗。咨询和护理与1型糖尿病女性相似。有妊娠期糖尿病史的女性在受孕前应接受咨询和检查,以发现隐匿性2型糖尿病。鉴于2型糖尿病与妊娠的高风险性质,必须由专业团队进行护理。