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一项初步研究，比较体外受精治疗后有植入失败史的女性与对照组中抑制素、激活素和卵泡抑素的子宫内膜表达。

A preliminary study comparing the endometrial expression of inhibin, activin and follistatin in women with a history of implantation failure after IVF treatment and a control group.

作者信息

Prakash A, Tuckerman E, Laird S, Ola B, Li T C, Ledger W L

机构信息

Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, UK.

出版信息

BJOG. 2008 Mar;115(4):532-6; discussion 536-7. doi: 10.1111/j.1471-0528.2007.01624.x.

DOI:10.1111/j.1471-0528.2007.01624.x
PMID:18271891
Abstract

The aim of this study was to evaluate the expression of activin: beta A and beta B subunit and follistatin in endometrium of women with implantation failure (n = 10) and compare it with a fertile control group (n = 7). Immunohistochemical staining intensity for follistatin in the endometrial glandular epithelium from women with implantation failure were significantly lower than that in control women (P = 0.03). The decreased expression of follistatin in epithelial cells in the endometrium of women with implantation failure after in vitro fertilisation (IVF) may suggest that follistatin may play a role in the implantation process.

摘要

本研究旨在评估激活素βA和βB亚基以及卵泡抑素在植入失败女性（n = 10）子宫内膜中的表达，并将其与可育对照组（n = 7）进行比较。植入失败女性子宫内膜腺上皮中卵泡抑素的免疫组化染色强度显著低于对照女性（P = 0.03）。体外受精（IVF）后植入失败女性子宫内膜上皮细胞中卵泡抑素表达降低，这可能表明卵泡抑素在植入过程中发挥作用。

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