MDR1基因的C3435T多态性与急性髓系白血病患者白血病原始细胞的P-糖蛋白功能及临床结局无关。
C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia.
作者信息
Hur Eun-Hye, Lee Je-Hwan, Lee Michael Jinpyo, Choi Seong-Jun, Lee Jung-Hee, Kang Mun Jung, Seol Miee, Jang Yae Eun, Lee Hee-Jung, Kang Ip-Sol, Shim Soo-Kyung, Ryu Seong-Gil, Kang Young-Ah, Lee Young-Shin, Park Chan-Jeoung, Chi Hyun-Sook, Lee Kyoo-Hyung
机构信息
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-2dong, Songpa-ku, Seoul, Republic of Korea.
出版信息
Leuk Res. 2008 Oct;32(10):1601-4. doi: 10.1016/j.leukres.2007.12.013. Epub 2008 Feb 12.
We investigated the association between the MDR1 C3435T polymorphism and P-glycoprotein function of leukemic blasts as well as clinical outcomes in 200 patients with AML, excluding the M3 subtype. The CC, CT and TT genotype frequencies of the C3435T polymorphism among patients were 71, 93 and 36, respectively. The C3435T polymorphism genotypes did not have influence on the P-glycoprotein function of leukemic blasts. Complete remission rates and overall, relapse-free and event-free survival rates were not significantly different among the C3435T polymorphism genotypes. In conclusion, the MDR1 C3435T polymorphism does not appear to have significant clinical implications in AML.
我们研究了200例非M3亚型急性髓系白血病（AML）患者中MDR1基因C3435T多态性与白血病原始细胞P-糖蛋白功能以及临床结局之间的关联。患者中C3435T多态性的CC、CT和TT基因型频率分别为71、93和36。C3435T多态性基因型对白血病原始细胞的P-糖蛋白功能没有影响。C3435T多态性基因型之间的完全缓解率、总生存率、无复发生存率和无事件生存率没有显著差异。总之，MDR1基因C3435T多态性在AML中似乎没有显著的临床意义。
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