Hsieh C C, Trichopoulos D
Department of Epidemology, Harvard School of Public Health, Boston, Massachusetts 02115.
Eur J Cancer. 1991;27(2):131-5. doi: 10.1016/0277-5379(91)90469-t.
Bra cup size and handedness were studied as possible risk factors for breast cancer. Data for 3918 cases and 11,712 controls from 7 centres were used to examine the association of handedness with laterality of breast cancer; data for 2325 cases and 7008 controls from 4 centres were used to assess the relation of bra cup size to breast cancer risk. There was a suggestive (P about 0.10) association of handedness with breast cancer laterality: odds ratio of a left-handed (or ambidextrous) woman having a left-sided cancer 1.22 (95% CI 0.96-1.56). Handedness may affect the lateral occurrence of breast cancer, although this tumour is in general more common in the left breast, possibly because this breast is usually slightly larger. Premenopausal women who do not wear bras had half the risk of breast cancer compared with bra users (P about 0.09), possibly because they are thinner and likely to have smaller breasts. Among bra users, larger cup size was associated with an increased risk of breast cancer (P about 0.026), although the association was found only among postmenopausal women and was accounted for, in part, by obesity. These data suggest that bra cup size (and conceivably mammary gland size) may be a risk factor for breast cancer.
研究了胸罩罩杯尺寸和用手习惯作为乳腺癌可能的风险因素。来自7个中心的3918例病例和11712例对照的数据用于检验用手习惯与乳腺癌发病侧别的关联；来自4个中心的2325例病例和7008例对照的数据用于评估胸罩罩杯尺寸与乳腺癌风险的关系。用手习惯与乳腺癌发病侧别存在提示性关联（P约为0.10）：左利手（或双手灵巧）女性患左侧乳腺癌的优势比为1.22（95%可信区间0.96 - 1.56）。用手习惯可能会影响乳腺癌的发病侧别，尽管这种肿瘤总体上在左乳更常见，可能是因为该侧乳房通常稍大一些。未穿胸罩的绝经前女性患乳腺癌的风险是穿胸罩女性的一半（P约为0.09），可能是因为她们更瘦且乳房可能更小。在穿胸罩的女性中，较大的罩杯尺寸与乳腺癌风险增加有关（P约为0.026），尽管这种关联仅在绝经后女性中发现，且部分可归因于肥胖。这些数据表明胸罩罩杯尺寸（以及可以想象的乳腺大小）可能是乳腺癌的一个风险因素。
