Owecki M, Miczke A, Pupek-Musialik D, Bryll W, Cymerys M, Nikisch E, Sowiński J
Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland.
Exp Clin Endocrinol Diabetes. 2008 Mar;116(3):173-7. doi: 10.1055/s-2007-992116. Epub 2008 Feb 14.
Although circulating adiponectin has been inversely correlated with obesity, type 2 diabetes and serum glycosylated hemoglobin (HbA1c) in humans, contradictory reports on that subject exist. In this study, serum concentrations of adiponectin in obese non-diabetic and diabetic humans were measured to examine whether they were associated with levels of HbA1c. The WHO definitions of obesity and diabetes were used. One hundred and five obese euglycemic subjects and 49 obese diabetics (aged 51+/-6.9, and 52+/-6.7 years, respectively) were studied. Their BMI, HbA1c and % of body fat were measured. Adiponectin was determined by an enzyme-linked immunosorbent assay. Although the serum adiponectin concentrations differed between diabetics and non-diabetics ( P<0.01), they were not correlated with HbA1c (r=-0.0814; P=0.5823, and r=-0.1861; P=0.1099, for diabetics and non-diabetics, respectively). Both diabetics and non-diabetics were segregated into tertiles according to their HbA1c levels. Plasma adiponectin did not differ significantly between the high (H), intermediate (I), and low (L) HbA1c tertiles.
Concentrations of adiponectin were not correlated with levels of glycosylated hemoglobin in the diabetic and non-diabetic subjects examined.
尽管循环脂联素在人类中与肥胖、2型糖尿病和血清糖化血红蛋白（HbA1c）呈负相关，但关于该主题存在相互矛盾的报道。在本研究中，测量了肥胖非糖尿病和糖尿病患者血清脂联素浓度，以检查它们是否与HbA1c水平相关。采用了世界卫生组织对肥胖和糖尿病的定义。研究了105名肥胖血糖正常的受试者和49名肥胖糖尿病患者（年龄分别为51±6.9岁和52±6.7岁）。测量了他们的体重指数、HbA1c和体脂百分比。通过酶联免疫吸附测定法测定脂联素。尽管糖尿病患者和非糖尿病患者的血清脂联素浓度不同（P<0.01），但它们与HbA1c均无相关性（糖尿病患者r=-0.0814；P=0.5823，非糖尿病患者r=-0.1861；P=0.1099）。根据HbA1c水平将糖尿病患者和非糖尿病患者均分为三分位数。高（H）、中（I）、低（L）HbA1c三分位数组之间的血浆脂联素无显著差异。
在所检查的糖尿病和非糖尿病受试者中，脂联素浓度与糖化血红蛋白水平无相关性。
