南亚人群中的脂肪细胞肥大、脂肪肝和代谢危险因素：族群健康与风险的分子研究（mol-SHARE）。
Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE).
机构信息
Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
出版信息
PLoS One. 2011;6(7):e22112. doi: 10.1371/journal.pone.0022112. Epub 2011 Jul 28.
OBJECTIVE
We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease.
RESEARCH DESIGN AND METHODS
We recruited 108 healthy South Asians (36.8 years) and white Caucasians (34.2 years) within three BMI strata. Body composition, adipocyte size, abdominal fat area, and hepatic adiposity were assessed and related to fasting glucose, insulin, lipids and adiponectin.
RESULTS
After adjustment for age, sex, and BMI, South Asians compared to white Caucasians had higher ln fasting insulin (mean difference (MD): 0.44; 95% CI: 0.20-0.69), lower HDL cholesterol (md: -0.13; 95% CI:-0.26 to -0.01), and lower adiponectin (md: -2.38; 95% CI: -3.59 to -1.17). South Asians also had more body fat (md: 2.69; 95% CI: 0.70 to 4.69), lower lean muscle mass (md: -3.25; 95%CI: -5.35 to -1.14), increased waist to hip ratio (md: 0.03; 95% CI: 0.01-0.05), less superficial subcutaneous abdominal adipose tissue (md: -2.94; 95% CI: -5.56 to-0.32), more deep/visceral to superficial adipose tissue ratio (md 0.34; 95% CI: 0.02 to 0.65), and more liver fat (md: 7.43%; 95% CI: 2.30 to 12.55%). Adipocyte area was increased in South Asians compared to white Caucasians (md: 64.26; 95% CI: 24.3 to 104.1) units(2). Adjustment for adipocyte area attenuated the ethnic differences in insulin (md: 0.22; 95% CI: -0.07 to 0.51), HDL (md: -0.01; 95% CI: -0.16 to 0.13) and adiponectin (md: -1.11; 95% CI: -2.61 to 0.39). Adjustment for differences in adipocyte area and fat distribution attenuated the ethnic difference in liver fat (md: 5.19; 95% CI: 0.31 to 10.06).
CONCLUSION
South Asians have an increased adipocyte area compared to white Caucasians. This difference accounts for the ethnic differences in insulin, HDL cholesterol, adiponectin, and ectopic fat deposition in the liver.
目的
我们旨在确定南亚人和白种高加索人之间脂肪组织分布和特征的差异是否导致了心血管疾病风险因素的差异。
研究设计和方法
我们在三个 BMI 分层中招募了 108 名健康的南亚人（36.8 岁）和白种高加索人（34.2 岁）。评估了身体成分、脂肪细胞大小、腹部脂肪面积和肝脂肪含量，并与空腹血糖、胰岛素、血脂和脂联素相关联。
结果
在调整年龄、性别和 BMI 后，与白种高加索人相比，南亚人具有更高的空腹胰岛素水平（平均差异（MD）：0.44；95%置信区间：0.20-0.69）、更低的高密度脂蛋白胆固醇（md：-0.13；95%置信区间：-0.26 至-0.01）和更低的脂联素（md：-2.38；95%置信区间：-3.59 至-1.17）。南亚人还具有更多的体脂肪（md：2.69；95%置信区间：0.70-4.69）、更低的瘦肌肉量（md：-3.25；95%CI：-5.35 至-1.14）、增加的腰围臀围比（md：0.03；95%置信区间：0.01-0.05）、较少的浅层皮下腹部脂肪组织（md：-2.94；95%置信区间：-5.56 至-0.32）、更多的深/内脏脂肪与浅层脂肪组织的比例（md 0.34；95%置信区间：0.02 至 0.65）和更多的肝脂肪（md：7.43%；95%置信区间：2.30 至 12.55%）。与白种高加索人相比，南亚人的脂肪细胞面积增加（md：64.26；95%置信区间：24.3 至 104.1）单位（2）。调整脂肪细胞面积后，胰岛素（md：0.22；95%置信区间：-0.07 至 0.51）、高密度脂蛋白（md：-0.01；95%置信区间：-0.16 至 0.13）和脂联素（md：-1.11；95%置信区间：-2.61 至 0.39）的种族差异减弱。调整脂肪细胞面积和脂肪分布的差异减弱了肝脏脂肪的种族差异（md：5.19；95%置信区间：0.31 至 10.06）。
结论
与白种高加索人相比，南亚人的脂肪细胞面积更大。这种差异解释了胰岛素、高密度脂蛋白胆固醇、脂联素和肝脏异位脂肪沉积的种族差异。
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