Ishibashi Masami, Ohtsuki Takashi
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Med Res Rev. 2008 Sep;28(5):688-714. doi: 10.1002/med.20123.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has been expected as a new anticancer strategy. During our studies on search for bioactive natural products from various natural resources such as plants and microorganisms, we recently identified several natural products which exhibited activities related to TRAIL signaling. Dimeric sesquiterpenoids isolated from Zingiberaceous plant, Curcuma parviflora, showed enhancement activity of gene expression of TRAIL-receptor and TRAIL-receptor protein level. Several new isoflavone natural products, named brandisianins, were isolated from Leguminosaeous plant, Millettia brandisiana, by our screening study targeting TRAIL-receptor expression enhancement activity. A dihydroflavonol (BB1) that was extracted from Compositaeous plant, Blumea balsamifera, and fuligocandin B, a new anthranilylproline-indole alkaloid isolated from myxomycete were found to exhibit reversal effect of TRAIL resistance activity.
肿瘤坏死因子（TNF）相关凋亡诱导配体（TRAIL）可诱导许多转化细胞凋亡，但对正常细胞无此作用，因此，它被视为一种新的抗癌策略。在我们从植物和微生物等各种自然资源中寻找生物活性天然产物的研究过程中，我们最近发现了几种与TRAIL信号传导相关的天然产物。从姜科植物小花莪术中分离出的二聚倍半萜类化合物显示出TRAIL受体基因表达增强活性以及TRAIL受体蛋白水平增强活性。通过我们针对TRAIL受体表达增强活性的筛选研究，从豆科植物布兰迪斯崖豆藤中分离出了几种新的异黄酮天然产物，命名为布兰迪斯异黄酮。从菊科植物艾纳香中提取的二氢黄酮醇（BB1）以及从黏菌中分离出的一种新的邻氨基苯甲酰基脯氨酸 - 吲哚生物碱富里戈坎丁B，被发现具有TRAIL抗性活性的逆转作用。
