Sampson M J, Chambers J B, Sprigings D C, Drury P L
Department of Diabetes, Kings College Hospital, London, UK.
Diabet Med. 1991 Feb-Mar;8(2):106-10. doi: 10.1111/j.1464-5491.1991.tb01554.x.
M-mode echocardiograms were recorded in 22 Type 1 diabetic patients with microalbuminuria (n = 10) or early persistent proteinuria (n = 12). Eight (36%) had both an increased left ventricular mass (males greater than 131 g m-2; females greater than 100 g m-2) and a systolic blood pressure above the 75th centile of the normal blood pressure distribution. These eight patients were treated with antihypertensive drugs, predominantly enalapril, for 1 year. Echocardiograms were repeated after 3 and 12 months. Systolic blood pressure at recruitment was 155 +/- 14 (+/- SD) mmHg, and was significantly lower after 3 months (146 +/- 12 mmHg; p less than 0.05) and 12 months (139 +/- 8 mmHg; p less than 0.005). Diastolic blood pressure did not change significantly. Both intraventricular septal width and left ventricular posterior wall thickness fell progressively and were significantly lower after 12 months treatment (15.0 +/- 2.7 vs 13.0 +/- 2.6 mm, and 10.3 +/- 1.9 vs 8.8 +/- 1.3 mm; both p less than 0.05). Left ventricular mass index was 148 +/- 29 g m-2 at recruitment, but lower after 3 months (131 +/- 25 g m-2; p less than 0.05) and 12 months (132 +/- 26 g m-2; p less than 0.005) antihypertensive therapy.
对22例1型糖尿病伴微量白蛋白尿（n = 10）或早期持续性蛋白尿（n = 12）的患者进行了M型超声心动图检查。其中8例（36%）患者既有左心室质量增加（男性大于131 g/m²；女性大于100 g/m²），又有收缩压高于正常血压分布的第75百分位数。这8例患者接受了以依那普利为主的降压药物治疗1年。在3个月和12个月后重复进行超声心动图检查。入组时收缩压为155±14（±标准差）mmHg，3个月后（146±12 mmHg；p<0.05）和12个月后（139±8 mmHg；p<0.005）显著降低。舒张压无显著变化。室间隔宽度和左心室后壁厚度均逐渐下降，治疗12个月后显著降低（分别为15.0±2.7 vs 13.0±2.6 mm，以及10.3±1.9 vs 8.8±1.3 mm；p均<0.05）。入组时左心室质量指数为148±29 g/m²，但在降压治疗3个月后（131±25 g/m²；p<0.05）和12个月后（132±26 g/m²；p<0.005）降低。
